Comparison of different formulas used for LDL calculation
DOI:
https://doi.org/10.5281/zenodo.7151824Keywords:
Cholesterol, Low-density lipoprotein, TriglycerideAbstract
Aim: Elevated low-density lipoprotein cholesterol concentration in the blood is a well-defined atherogenic risk factor and it is highly predictive for Coronary Heart Disease. Therefore, the analysis of serum low-density lipoprotein cholesterol levels must be carried out in both accuartely and precisely. This study was designed to compare the results obtained with directly measured low-density lipoprotein cholesterol in our hospital and various formulas used to calculate low-density lipoprotein cholesterol.
Materials and Methods: 175 patients with directly measured low-density lipoprotein cholesterol results were included in the study. Patient results were divided into four groups based on their triglyceride values. low-density lipoprotein cholesterol values were calculated using 11 different formulas by using the results of total cholesterol, triglyceride, and high-density lipoprotein cholesterol of the patients. For each patient group, directly measured low-density lipoprotein cholesterol and low-density lipoprotein cholesterol values calculated with formulas were evaluated in terms of correlation.
Results: As a result, a single formula that was valid in all groups could not be determined, but instead, it was obvious that formulas that could be valid at different triglyceride levels came to the fore.
Conclusions: It seems that the best formula for low-density lipoprotein cholesterol estimation in the Turkish population is not yet available, but we think that different formulas can be preferred according to the triglyceride levels of the patients. In addition, it would be beneficial to develop a new formula by conducting new studies according to the Turkish population.
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