Comparison of alternative acute phase reactants in the evaluation of the prognosis of COVID-19 patients

Authors

  • Cigdem Yucel University of Health Sciences, Gulhane Training and Research Hospital Clinical Biochemistry Department, Ankara/Turkey
  • Erdim Sertoglu University of Health Sciences, Gulhane Training and Research Hospital Clinical Biochemistry Department, Ankara/Turkey
  • Ahmet Rifat Balik University of Health Sciences, Gulhane Training and Research Hospital Clinical Biochemistry Department, Ankara/Turkey
  • Sebla Ertugrul University of Health Sciences, Gulhane Training and Research Hospital Clinical Biochemistry Department, Ankara/Turkey
  • Canturk Tasci University of Health Sciences, Gulhane Training and Research Department of Pulmonology, Ankara-Turkey
  • Ozlem Yavuz University of Health Sciences, Gulhane Training and Research Hospital Clinical Biochemistry Department
  • Taner Ozgurtas University of Health Sciences, Gulhane Training and Research Hospital Clinical Biochemistry Department

DOI:

https://doi.org/10.5281/zenodo.7519953

Keywords:

COVID-19,, acute phase reactants, neopterin, adenosine deaminase, chitotriosidase

Abstract

Aim: Acute phase reactants (APR) and their release pattern is important in cytokine storm related with poor prognosis in COVID-19 patients. The cytokine storm is basically caused by interleukin-6 (IL-6). However, a variety of APRs are thought to be related to disease severity. The present study is focused on evaluation of alternative acute phase reactants in COVID-19 patients.

Materials and Methods: 121 participants were included in the study.  They were divided in to 3 groups as IL-6 level < 35 pg/ml (group 1) , IL-6 level > 35 pg/mL (group 2) , and healthy controls (group 3) . Levels of altenatice APRs neopterin, adenosine deaminase (ADA) and Chitotriosidase were evaluated in study groups together with routinely studied inflammation markers.

Results: Neopterin values were significantly different in all study groups. Chitotriosidase levels were similar bewteen group 1 and group 2 while there was a statistically significant difference between group 1 and group 3, group 2 and group 3 and also a difference in comparison of all groups together. ADA levels were only significantly different between group 1 and group 3. Among the study parameters, neopterin showed moderate correlation wtih IL-6. Neopterin also showed week moderate correlations with NLR and fibrinogen.

Conclusion: Neopterin can be a candidate APR and a prognostic marker for COVID-19. It can can be accepted as a marker of poor prognosis, lung damage, and high morbidity in COVID-19, alongside IL-6.

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Published

2023-01-10

How to Cite

Yucel, C., Sertoglu, E., Balik, A. R., Ertugrul, S., Tasci, C., Yavuz, O., & Ozgurtas, T. (2023). Comparison of alternative acute phase reactants in the evaluation of the prognosis of COVID-19 patients. Journal of Social and Analytical Health, 3(1), 7–12. https://doi.org/10.5281/zenodo.7519953

Issue

Vol. 3 No. 1 (2023): JOURNAL OF SOCIAL AND ANALYTICAL HEALTH

Section

Orijinal Articles

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