Oksidatif stres ve antioksidan savunma sistemlerinin glial tümörler ile ilişkisi

Yazarlar

  • Berzan Ekmen Lokman Hekim Üniversitesi, Sağlık Hizmetleri Meslek Yüksek Okulu, Tıbbi Laboratuvar Programı, Ankara, Türkiye https://orcid.org/0000-0001-6260-6196
  • Demet Kaçaroğlu Lokman Hekim Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Ana Bilim Dalı, Ankara, Türkiye

DOI:

https://doi.org/10.5281/zenodo.7766207

Anahtar Kelimeler:

Oksidatif stres, Glioma, Antioksidanlar, Oksidatif Stres Parametreleri

Özet

Gliomalar yetişkin popülasyonda en sık görülen beyin tümörleridir ve güncel tedaviler etkili değildir. Bu tümör grubunda küratif bir tedavi geliştirilebilmesi için glial hücrelerin tümöre dönüşümüne neden olan biyolojik ve biyokimyasal mekanizmaların aydınlatılması oldukça önemlidir. Beyin tümörlü olgularda endojen enzimatik ve enzimatik olmayan antioksidan savunma sistemlerinde bozukluk söz konusudur. Bu dengenin bozulmasından dolayı merkezi sinir sistemi içerisinde oluşan yüksek oksidatif stres sağlıklı hücrelerde metabolik ve genetik hasarı indükler. Hipoksi sonucunda ortamda biriken serbest radikaller sıklıkla glioma gibi beyin tümörlerinde birikerek nekrotik ölümün artmasına ve tümör hücreleriyle çevrili nekrotik bölgelerin oluşumuna neden olur. Bu derlemede, serbest radikallerin üretimi ile antioksidan mekanizma arasındaki dengesizliğin, gliomaların gelişimi ve ilerlemesindeki rolünü incelemeyi amaçladık. Ayrıca, bozulan redoks denge durumunun kansere bağlı indüklenen apoptozis üzerindeki etkilerini de moleküler mekanizmaları ile irdelemeyi hedefledik.  Bu derleme çalışmasının, glioma tedavisinde redoks mikroortamının düzeltilmesine katkı sağlayacak yeni farmakolojik terapötiklerin geliştirilmesi için faydalı olacağını düşünmekteyiz.

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İndir

Yayınlanmış

2023-03-24

Nasıl Atıf Yapılır

Ekmen, B., & Kaçaroğlu, D. (2023). Oksidatif stres ve antioksidan savunma sistemlerinin glial tümörler ile ilişkisi . Journal of Social and Analytical Health, 3(2), 177–185. https://doi.org/10.5281/zenodo.7766207