Forthcoming

Allojenik kök hücre nakli ve koruyucu izolasyon sürecinde hasta ve yakınları tarafından algılanan sosyal destek ve ruh sağlığının incelenmesi: tek merkez deneyimi

Yazarlar

  • Nesiba Kalyoncu Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Consultation Liaison Psychiatry, İstanbul, Türkiye
  • Ayşenur Çetin Üçeriz Department of Nursing, Halic University, Faculty of Health Sciences, Istanbul, Türkiye
  • İpek Yönal Hindilerden İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, Türkiye
  • Ayşe Kobak İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, Türkiye
  • Hayriye Ulu Istanbul Training and Research Hospital, Department of Internal Medicine, Division of Hematology, İstanbul, Türkiye
  • Seher Yeşilal Marmara University, Pendik Training and Research Hospital, Department of Internal Medicine, Division of Hematology, İstanbul, Türkiye
  • Tarık Onur Tiryaki İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, Türkiye
  • Meliha Nalçacı İstanbul University, İstanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology, İstanbul, Türkiye

Anahtar Kelimeler:

hematopoetik kök hücre nakli, hemşirelik bakımı, ruh sağlığı, sosyal destek

Özet

Amaç: Hematopoetik Kök Hücre Nakli (HKHN), hematolojik kanserlerin tedavisinde agresif bir yöntem olarak tercih edilmektedir. Yüksek doz kemoterapi, izolasyon süreci ve nakil sonrası komplikasyonlar, hasta ve yakınları için biyopsikososyal anlamda önemli stres kaynaklarıdır. Literatürde, HKHN sürecinde psikiyatrik destek sağlanması ve ruh sağlığının korunmasının önemi vurgulanmaktadır. Bu bağlamda, araştırma, HKHN sürecinde hasta ve yakınlarının algıladıkları sosyal destek ve ruh sağlığındaki değişimleri incelemeyi amaçlamaktadır. Gereç ve Yöntem: Longitudinal ve prospektif tipte olan araştırmada, son üç yılın nakil sayıları dikkate alınarak evren belirlenmiş; örneklem büyüklüğü ise G*Power 3.1 programıyla %95 güven, %90 güç analizi kullanılarak her grup için minimum 13 olarak hesaplanmıştır. Veriler Haziran 2022-2023 arasında toplanmış olup, demografik bilgi formu, DASS-21, Distres Termometresi (DT) ve Çok Boyutlu Algılanan Sosyal Destek Ölçeği (ÇBASDÖ) kullanılarak üç ölçümde gerçekleştirilmiştir. Bulgular: Katılımcılar ortalama 48,77 yaşında olup %7,7'sinin psikiyatrik hastalık geçmişi olduğu bulunmuştur. Hasta yakınlarının yaş ortalaması 42,38 olarak tespit edilmiştir. DT puanları istatistiksel olarak anlamlı değilken, DASS-21 ve ÇBASDÖ skorları da zamansal ve grup farklılıkları açısından anlamlı bulunmamıştır (p>0.05). Bununla birlikte, hastaların üçte biri ve hasta yakınlarının yarısının psikolojik sorun açısından anlamlı puanlara sahip olduğu görülmüştür. Sonuç: HKHN sürecinde fiziksel, psikolojik ve sosyal zorlukların multidisipliner yaklaşımla ele alınması, ruhsal problemlerin erken fark edilmesi açısından önemlidir.

Referanslar

Khaddour K, Hana CK, Mewawalla P. Hematopoietic Stem Cell Transplantation. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30725636.

Erdal S, Dikbıyık G, Yazgaç R, Beköz HS, Can G. Hematopoietik kök hücre nakli hastalarında etkileşimsel eğitim yaklaşımının anksiyete düzeyine etkisi. Hemşirelik Bilimi Dergisi, 2020;3(3):22-27.

McErlean G, Tapp C, Brice L, Gilroy N, Kabir M, Greenwood M, Larsen SR, Moore J, Gottlieb D, Hertzberg M, Brown L, Hogg M, Huang G, Ward C, Kerridge I. Predictors of post traumatic growth in allogeneic hematopoietic stem cell transplantation survivors: a cross-sectional survey. BMC Psychol. 2023;16(11):235. doi: 10.1186/s40359-023-01204-4.

Shen Z, Shi S, Li C, Ruan C. The influence of social constraints on the quality of life of hematopoietic stem cell transplantation survivors: The chain mediating effect of illness perceptions and the fear of cancer recurrence. Front. Psychol., 2022;13:1017561. doi: 10.3389/fpsyg.2022.1017561

Vinette B, Bilodeau K. Progression of self-management learning experiences of young adults following an allogeneic hematopoietic stem cell transplantation: A qualitative study. Eur J Oncol Nurs., 2021;52. doi: 10.1016/j.ejon.2021.101951.

Passweg JR, Baldomero H, Chabannon C, Basak GW, Corbacioglu S, Duarte R, Dolstra H, Lankester AC, Mohty M, Montoto S, Peffault de Latour R, Snowden JA, Styczynski J, Yakoub-Agha I, Kröger N, European Society for Blood and Marrow Transplantation (EBMT). The EBMT activity survey on hematopoietic-cell transplantation and cellular therapy: CAR-T's come into focus. Bone Marrow Transplant. 2020;55:1604–13.

Sözeri Öztürk E, Kutlutürkan S. Otolog kök hücre infüzyonu sırasında yaşanan bulantı kusmanın yönetiminde farmakolojik olmayan uygulamalar. Cukurova Med J. 2018;43(4):1068-1070.

Türkiye Kök Hücre Koordinasyon Merkezi (TURKOK) (2018). [homepage on the Internet]. Available at:https://turkok.saglik.gov.tr (Accessed 1 April 2024).

Campo RA, Wu LM, Austin J, Valdimarsdottir H, Rin C. Personal resilience resources predict post-stem cell transplant cancer survivors’ psychological outcomes through reductions in depressive symptoms and meaning-making. J Psychosoc Oncol. 2017;35(6):666–687.

Karacan Y, Kapucu SS. (2010). Periferik kök hücre naklinde hastalarda görülen anksiyete ve depresyon. Anadolu Hemşirelik ve Sağlık Bilimleri Dergisi, 2010;13(1);77-82.

Seo HJ, Baek YG, Cho BS, Kim TS, Um YH, Chae JH. Anxiety and depression of the patients with hematological malignancies during hospitalization for hematopoietic stem cell transplantation. Psychiatry Investig. 2019;16(10):751-758. doi: 10.30773/pi.2019.07.12.

Uzşen H, Başbakkal Z. Kemik iliği transplantasyon ünitesinde tedavi gören çocuk hastalarda psikososyal hemşirelik yaklaşımı. Samsun Sağlık Bilimleri Dergisi, 2021;1(6):1-10.

Ehrlich KB, Miller GE, Scheide T, Baveja S, Weiland R, Galvin J, Mehta J, Penedo FJ. Pre-transplant emotional support is associated with longer survival after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation, 2016;51(12):1594–1598.

Karacan Y, Kapucu SS. Otolog ve allojenik kök hücre nakli olan hastaların anksiyete ve depresyon düzeyi. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 2013;39(2):93-99.

Simoneau TL, Mikulich-Gilbertson SK, Natvig C, Kilbourn K, Spradley J, Grzywa-Cobb R, Philips S, McSweeney P, Laudenslager ML. Elevated peri-transplant distress in caregivers of allogeneic blood or marrow transplant patients. Psycho-oncology, 2013;22(9): 2064–2070.

Rivera Rivera JN, Burris JL, A systematic literature review and head-to-head comparison of social support and social constraint in relation to the psychological functioning of cancer survivors. Ann. Behav. Med. 2020;54:176–192. doi: 10.1093/abm/kaz037

Lepore SJ, Revenson TA. Social constraints on disclosure and adjustment to cancer. Social and Personality Psychol Compass: Health, 2007;1:313–333.

You J, Lu Q. Social constraints and quality of life among chinese-speaking breast cancer survivors: a mediation model. Qual. Life Res. 2014;23:2577–2584. doi: 10.1007/s11136-014-0698-4

Izgu N. Caregiving burden and nursing care in primary caregivers of patients undergoing hematopoietic stem cell transplantation. Journal of Hacettepe University Faculty of Nursing, 2014;2(1): 61-69.

Tüysüz Y. Determining the feelings and thoughts of hematopoietic stem cell transplant patients and caregivers about the treatment process. Master's thesis, Institute of Health Sciences, 2020.

Utz RL, Warner EL. Caregiver burden among diverse caregivers. Cancer, 2022;128(10): 1904–1906. https://doi.org/10.1002/cncr.34171

Datta SS, Mukherjee A, Randall J. Psychosocial management of patients undergoing HSCT and donors of stem cells. Contemporary Bone Marrow Transplantation, 2021;627-639. https://doi.org/10.1007/978-3-030-36358-1_10

Kim M, Kim TG, Beom SH. Physical and psychological discomfort experienced by hematopoietic stem-cell donors. International Journal of Environmental Research and Public Health, 2020;17(7):2316. https://doi.org/10.3390/ijerph17072316.

Tiryaki N. Qualitative investigation of psychosocial problems of bone marrow donors related to stem cell collection process. Master's thesis, Institute of Health Sciences, 2018.

Janicsák H, Ungvari GS, Gazdag G. Psychosocial aspects of hematopoietic stem cell transplantation. World J Transplant. 2021;11(7):263-276.

Corman M., Rubio M. T., Cabrespine A., Brindel I., Bay J. O., Peffault De La Tour R., Dambrun M. Mental health and quality of life of patients undergoing hematopoietic stem cell transplantation (HSCT) prior to hospitalization: a cross-sectional complete state health study. Health Psychology and Behavioral Medicine, 2021;9(1):70–83 https://doi.org/10.1080/21642850.2021.1873140.

Nakamura ZM, Nash RP, Quillen LJ, Richardson DR, McCall RC, Park EM. (2019). Psychiatric care in hematopoietic stem cell transplantation. Psychosomatics, 2019;60(3):227–237.

Niedzwiedz CL, Knifton L, Robb KA, Katikireddi SV, Smith DJ Depression and anxiety among people living with and beyond cancer: a growing clinical and research priority. BMC Cancer, 2019;19(1):943.

Andrykowski MA, Bishop MM, Hahn EA, Cella DF, Beaumont JL, Brady M., Horowitz MM, Sobocinski KA, Rizzo JD, Wingard JR. Long-term health-related quality of life, growth, and spiritual well-being after hematopoietic stem-cell transplantation. J Clin Oncol. 2005; 23(3): 599-608.

Bergkvist K, Larsen J, Johansson UB, Mattsson J, Fossum B. Family members' life situation and experiences of different caring organizations during allogeneic hematopoietic stem cells transplantation - a qualitative study. Eur. J. Canc. Remedy. 2018;27:1–9.

Poloméni A, Lapusan S, Bompoint C, Rubio MT, Mohty M. The impact of allogeneic-hematopoietic stem cell transplantation on patients' and close relatives' quality of life and relationships. Eur J Oncol Nurs. 2016;21:248-256. doi: 10.1016/j.ejon.2015.10.011.

Posluszny D M, Bovbjerg DH, Syrjala KL, Agha M, Dew MA. (2019). Correlates of anxiety and depression symptoms among patients and their family caregivers prior to allogeneic hematopoietic cell transplant for hematological malignancies. Supportive Care in Cancer. 2019;27:591-600.

Fife BL, Von Ah DM, Spath ML, Weaver MT, Yang Z, Stump T, Farag S. (2017). Preliminary efficacy of a brief family intervention to prevent declining quality of life secondary to parental bone marrow transplantation. Bone Marrow Transplantation, 2017;52(2): 285-291.

Sannes TS, Simoneau TL, Mikulich-Gilbertson SK, Natvig CL, Brewer BW, Kilbourn K, Laudenslager ML. Distress and quality of life in patient and caregiver dyads facing stem cell transplant: identifying overlap and unique contributions. Support Care Cancer, 2019;27(6):2329–2337. https://doi.org/10.1007/s00520-018-4496-3

Waldman LP. Nelson AM, Jacobs JM, Gray TF, Clay M, Jagielo AD, ... , Al-Yang Y, Pan W, Farag SS, Von Ah D. Effect of family cohesion on symptom distress during hematopoietic stem cell transplantation. Support Care, 2022;30(2):1731-1737. DOI: 10.1007/S00520-021-06593-Z. Epub 2021 Sep 28. PMID: 34585301.

Sever M, İl S. Kök hücre nakli olan hematoloji hastalarının sorun ve gereksinimleri: kurumsal hizmetlerin değerlendirilmesi. Tıbbi Sosyal Hizmet Dergisi. 2019;13:70-89.

Kent EE, Rowland JH, Northouse L, Litzelman K, Chou WYS, Shelburne N, Timura C, O’Mara A, Huss K. Caring for caregivers and patients: research and clinical priorities for ınformal cancer caregiving. Cancer, 2016;122(13):1987-1995.

Langer S, Yi J, Chi NC, Lindhorst T. Psychological ımpacts and ways of coping reported by spousal caregivers of hematopoietic cell transplant recipients: a qualitative analysis. Biol Blood Marrow Transplant. 2020;26(4):764-771. doi: 10.1016/j.bbmt.2019.11.023.

Kim J, Jang M. Stress, social support, and sexual adjustment in married female patients with breast cancer in korea. Asia-Pacific Journal of Oncology Nursing. 2019;7(1):28–35. https://doi.org/10.4103/apjon.apjon_31_19

Serbest Z, Sayar S. Stressful situations and strategies for coping with stress in cancer patients receiving chemotherapy: A descriptive and cross-sectional study. Turkiye Klinikleri Journal of Nursing Sciences, 2023;15(3).

Yardımcı G. The effect of perceived social support on posttraumatic stress disorder in women diagnosed with gynecologic oncology. Master's thesis, Hitit University Graduate Education Institute, 2023.

Song Y, Chen S, Roseman J, Scigliano E, Redd WH, Stadler G. It takes a team to make it through: the role of social support for survival and self-care after allogeneic hematopoietic stem cell transplant. Frontiers in Psychology. 2021;12: 624906.

Hauken MA, Larsen TMB. Young adult cancer patients' experiences of private social network support during cancer treatment. J. Clin. Nurs. 2019;28:2953–2965. doi: 10.1111/jocn.14899

Bergkvist K, Winterling J, Kisch AM. Support in the context of allogeneic hematopoietic stem cell transplantation-The perspectives of family caregivers. European Journal of Oncology Nursing. 2020;46:101740.

Yayınlanmış

2025-04-02

Nasıl Atıf Yapılır

Kalyoncu, N., Çetin Üçeriz, A., Yönal Hindilerden, İpek, Kobak, A., Ulu, H., Yeşilal, S., … Nalçacı, M. (2025). Allojenik kök hücre nakli ve koruyucu izolasyon sürecinde hasta ve yakınları tarafından algılanan sosyal destek ve ruh sağlığının incelenmesi: tek merkez deneyimi. Journal of Social and Analytical Health, 5(2). Geliş tarihi gönderen https://jsoah.com/index.php/jsoah/article/view/142

Sayı

Cilt 5 Sayı 2 (2025): JOURNAL OF SOCIAL AND ANALYTICAL HEALTH

Bölüm

Araştırma Makalesi

Lisans

Telif Hakkı (c) 2025 Journal of Social and Analytical Health

Creative Commons License

Bu çalışma Creative Commons Attribution-NonCommercial 4.0 International License ile lisanslanmıştır.