The association of oxidative stress and antioxidant defense systems on glial tumors


  • Berzan Ekmen Lokman Hekim Üniversitesi, Sağlık Hizmetleri Meslek Yüksek Okulu, Tıbbi Laboratuvar Programı, Ankara, Türkiye
  • Demet Kacaroglu Lokman Hekim Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Ana Bilim Dalı, Ankara, Türkiye



Oxidative stress, Glioma, Antioxidants, Oxidative Stress Parameters


Gliomas are the most common brain tumors in the adult population, and current adjuvant treatments are not effective. In order to develop a curative treatment for this group of tumors, it is very important to clarify the biological and biochemical mechanisms that cause the transformation of glial cells into tumors. In patients with brain tumors, there is a deficiency in the endogenous enzymatic and non-enzymatic antioxidant defense systems. Due to the disruption of this balance, the high oxidative stress that occurs in the central nervous system induces metabolic and genetic damage to healthy cells. Free radicals accumulated in the environment as a result of hypoxia accumulate in brain tumors, which leads to an increase in necrotic death. In this review, we examined the effects of the relationship between free radical production and antioxidant mechanism systems on glioma development and progression. In addition, we aimed to examine the effects of the disrupted redox equilibrium state on cancer-induced apoptosis with its molecular mechanisms. We believe that this review study will be useful for the development of new pharmacological therapeutics that will contribute to the regulation of the redox microenvironment in the treatment of glioma.


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How to Cite

Ekmen, B., & Kacaroglu, D. (2023). The association of oxidative stress and antioxidant defense systems on glial tumors . Journal of Social and Analytical Health, 3(2), 177–185.