Cytokine gene expression in ligamentum flavum hypertrophy
Keywords:Lumbar Spinal Canal Stenosis, Ligamentum Flavum Hypertrophy, Spinal Stenosis, Cytokine, Fibrosis
Aim: Lumbar spinal canal stenosis is a disease is an important reason of injury in the elderly and the most important reason of spinal surgery in patients above the age of 65. Ligamentum flavum hypertrophy plays a critical role in the pathogenesis of lumbar spinal canal stenosis. Inflammatory agents induce the ligamentum flavum hypertrophy and increased scar tissue formation. Even though its prevalence, lumbar spinal stenos does not have a universal definition in this day and age and its generally accepted radiologic diagnosis criteria is lacking.
Material and Methods: In our study, 25 samples of hypertrophied LF tissue were obtained from the patients with the diagnosis of lumbar spinal canal stenosis while 25 samples were obtained from the patients who underwent surgery for lumbar disc herniation forming control group. Samples were investigated for histological study. Lumbar spinal canal stenosis and control groups were investigated for the expression of inflammatory cytokine genes by semiquantitative RT-PCR method.
Results: Cytokines were found both in lumbar spinal canal stenosis and control groups. Any statistically significant difference was not found between lumbar spinal canal stenosis and control groups in terms of some cytokines. However, low levels of IL-1 beta were found in lumbar spinal canal stenosis group.
Conclusions: Spinal canal stenosis is the most important reason of pain and decrease in functional capacity in elderly patients. Therefore, effective therapeutic strategies are needed. Drug resistance is common in fibrotic tissue. Antifibrotic drugs can be an important part of a targeted drug development strategy.
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