TY - JOUR AU - Yucel, Cigdem AU - Sertoglu, Erdim AU - Balik, Ahmet Rifat AU - Ertugrul, Sebla AU - Tasci, Canturk AU - Yavuz, Ozlem AU - Ozgurtas, Taner PY - 2023/01/10 Y2 - 2024/03/29 TI - Comparison of alternative acute phase reactants in the evaluation of the prognosis of COVID-19 patients JF - Journal of Social and Analytical Health JA - J. Soc. Anal. Health VL - 3 IS - 1 SE - Orijinal Articles DO - 10.5281/zenodo.7519953 UR - https://jsoah.com/index.php/jsoah/article/view/72 SP - 7-12 AB - <p>Aim: Acute phase reactants (APR) and their release pattern is important in cytokine storm related with poor prognosis in COVID-19 patients. The cytokine storm is basically caused by interleukin-6 (IL-6). However, a variety of APRs are thought to be related to disease severity. The present study is focused on evaluation of alternative acute phase reactants in COVID-19 patients.</p><p>Materials and Methods: 121 participants were included in the study.  They were divided in to 3 groups as IL-6 level &lt; 35 pg/ml (group 1) , IL-6 level &gt; 35 pg/mL (group 2) , and healthy controls (group 3) . Levels of altenatice APRs neopterin, adenosine deaminase (ADA) and Chitotriosidase were evaluated in study groups together with routinely studied inflammation markers.</p><p>Results: Neopterin values were significantly different in all study groups. Chitotriosidase levels were similar bewteen group 1 and group 2 while there was a statistically significant difference between group 1 and group 3, group 2 and group 3 and also a difference in comparison of all groups together. ADA levels were only significantly different between group 1 and group 3. Among the study parameters, neopterin showed moderate correlation wtih IL-6. Neopterin also showed week moderate correlations with NLR and fibrinogen.</p><p>Conclusion: Neopterin can be a candidate APR and a prognostic marker for COVID-19. It can can be accepted as a marker of poor prognosis, lung damage, and high morbidity in COVID-19, alongside IL-6.</p> ER -